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The Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents from AIDSinfo summarize Baseline Evaluation, Laboratory Testing, Considerations for Antiretroviral Use in Patients with Coinfections, Limitations to Treatment Safety and Efficacy, and Drug Interactions. The guidelines include a table format presenting antiretroviral-associated adverse events by drug class. Significant changes from the previous version of the guidelines are highlighted in yellow throughout the document.